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Hundreds of Studies Indicating Health Damage from Fluoride Exposure

Updated: May 3


A compilation of known health effects and associated studies can be found at FluorideAlert.org

Fluoride exposure has been linked to health damage and to the exacerbation of underlying health conditions including: arthritis and joint pain, kidney dysfunction, thyroid dysfunction, endocrine disruption, cardiovascular damage, softening and de-mineralizing of the bones (osteomalacia), increase in bone fractures, skeletal and dental fluorosis, neurotoxicity and cognitive effects, lowered IQ in children, gastrointestinal disorders, calcification of the pineal gland, diabetes and blood glucose regulation problems, cancer, oxidative stress, and male reproductive damage, among others.


It's important to note that there is no conclusive evidence of the universal safety of water fluoridation.


Fluoride accumulates in the body over time. This means that even tiny doses can accumulate and cause health damage over time, especially if people are exposed daily via fluoridated water. People with kidney or liver dysfunction or other detoxification problems are at an increased risk for toxic fluoride accumulation in the body.

People at greater risk of health damage from water fluoridation include:


- fetuses and babies

- children

- people with arthritis, joint problems, or skeletal or dental fluorosis

- people with thyroid dysfunction

- people with chemical sensitivities

- people who have been injured by fluorine-infused pharmaceuticals or have a family history of these types of injuries

- people with ADHD, autism, or other cognitive issues linked to chemical toxicity

- people with cognitive decline

- people with diabetes or blood sugar regulation problems

- people with sensitive kidneys or kidney dysfunction

- people with hindered detoxification

- people with a personal or family history of cardiovascular damage or disease

- people with a personal or family history of cancer

This is a sampling of studies and links showing health damage from fluoride exposure:

OVERVIEW OF TOXICITY

Fluoride in drinking water: a scientific review of EPA's standards (2006)

Link: https://nap.nationalacademies.org/read/11571/chapter/1

NEUROTOXICITY, COGNITIVE EFFECTS, AND LOWERED IQ SCORES IN CHILDREN

Over 200 animal studies showing that prolonged exposure to varying levels of fluoride can damage the brain, particularly when coupled with an iodine deficiency or aluminum excess

Link: https://fluoridealert.org/studytracker/?effect=brain-2&sub=cellulartissue-damage&type=animals&start_year=&end_year=&fulltext=&fantranslation=

74 human studies linking fluoride exposure with reduced intelligence

Link: https://fluoridealert.org/studies/brain01/

Over 60 animal studies reporting that mice or rats ingesting fluoride have an impaired capacity to learn and/or remember

Link: https://fluoridealert.org/studies/brain02_/


Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915186/


Neurobehavioural effects of developmental toxicity (autism, ADHD, dyslexia, cognitive impairment)

Link: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70278-3/fulltext

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491930/

Fluoride exposure from infant formula and child IQ in a Canadian birth cohort

Link: https://www.sciencedirect.com/science/article/pii/S0160412019326145?via%3Dihub


Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico

Link: https://ehp.niehs.nih.gov/doi/10.1289/ehp655


Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704756/


Neurotoxicity of sodium fluoride in rats

Link: https://pubmed.ncbi.nlm.nih.gov/7760776/

ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)


Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth

Link: https://www.sciencedirect.com/science/article/pii/S0160412019315971

Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association

Link: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0003-1


Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years of age in Mexico City

Link: https://www.sciencedirect.com/science/article/pii/S0160412018311814?via%253Dihub

ARTHRITIS, SKELETAL FLUOROSIS, AND BONE DAMAGE

Arthritis

Link: https://fluoridealert.org/issues/health/arthritis/


Fluoride in Drinking Water: A Review on the Status and Stress Effects

Link: https://www.researchgate.net/publication/233357494_Fluoride_in_Drinking_Water_A_Review_on_the_Status_and_Stress_Effects


Skeletal fluorosis from brewed tea

Link: https://pubmed.ncbi.nlm.nih.gov/21593111/


What Is Your Guess? A Case of Thick but Brittle Bones and Instant Tea

Link: https://academic.oup.com/clinchem/article/56/6/1041/5622483


Fluoride-related bone disease associated with habitual tea consumption

Link: https://pubmed.ncbi.nlm.nih.gov/17550752/

Report of Investigations on Adult Hand Osteoarthritis in Fengjiabao Village, Asuo Village, and Qiancheng Village

Link: https://fluoridealert.org/bao-2003/

MALE INFERTILITY


60+ animal studies linking fluoride exposure to male reproductive damage

Link: https://fluoridealert.org/studies/fertility02/

In vitro influence of sodium fluoride on ram semen quality and enzyme activities

Link: https://www.semanticscholar.org/paper/In-vitro-influence-of-sodium-fluoride-on-ram-semen-Zakrzewska-Uda%C5%82a/5ec7865f43a1e500e8a798d80b7633f32e9b9be2


Toxic effects of fluoride on reproductive ability in male rats: sperm motility, oxidative stress, cell cycle, and testicular apoptosis.

Link: https://www.semanticscholar.org/paper/Toxic-effects-of-fluoride-on-reproductive-ability-Junling-Yingmei/568e3e54d6d332107090bfafa1eb7dad95056f26


KIDNEY DISEASE AND DYSFUNCTION


Kidney disease

Link: https://fluoridealert.org/issues/health/kidney/

Fluoride as a cause of kidney disease in humans

Link: https://fluoridealert.org/studies/kidney07/


Kidney damage in fluoride-exposed animals

Link: https://fluoridealert.org/studies/kidney08/


Back pain in chronic renal failure

Link: https://academic.oup.com/ndt/article/21/8/2331/1820840


"Main sources of fluoride include food and water. About 50–70% of fluoride is excreted by the kidneys [1]. Individuals with kidney disease have decreased ability to excrete fluoride in urine and are at risk of developing fluorosis even at normal recommended limit of 0.7 to 1.2 mg/l (37–63 µmol/l) of fluoride in drinking water [2]."


Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population

Link: https://pubmed.ncbi.nlm.nih.gov/9800387/


Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence

Link: https://www.researchgate.net/publication/5930763_Fluoridation_of_drinking_water_and_chronic_kidney_disease_Absence_of_evidence_is_not_evidence_of_absence



CARDIOVASCULAR DAMAGE


Cardiovascular disease

Link: https://fluoridealert.org/issues/health/cardio/

Drinking water fluoride and blood pressure? An environmental study

Link: https://pubmed.ncbi.nlm.nih.gov/21484404/


Association of vascular fluoride uptake with vascular calcification and coronary artery disease

Link: https://pubmed.ncbi.nlm.nih.gov/21946616/


Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta

Link: https://pubmed.ncbi.nlm.nih.gov/22422340/


Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children

Link: https://pubmed.ncbi.nlm.nih.gov/21342861/


Effects of sodium fluoride on the electrocardiogram of male rabbits

Link: https://www.researchgate.net/publication/235906983_Effects_of_sodium_fluoride_on_the_electrocardiogram_of_male_rabbits


Alterations in Electrocardiographic Parameters after Subacute Exposure of Fluoride and Ameliorative Action of Aluminium Sulphate in Goats

Link: https://www.researchgate.net/publication/26715181_Alterations_in_Electrocardiographic_Parameters_after_Subacute_Exposure_of_Fluoride_and_Ameliorative_Action_of_Aluminium_Sulphate_in_Goats

Effects of chronic fluorosis on electrocardiogram in sheep

Link: https://pubmed.ncbi.nlm.nih.gov/12746571/


Histopathology of myocardial damage in experimental fluorosis in rabbits

Link: https://www.researchgate.net/publication/228361564_Histopathology_of_myocardial_damage_in_experimental_fluorosis_in_rabbits


Chronic fluoride toxicity and myocardial damage: antioxidant offered protection in second generation rats

Link: https://pubmed.ncbi.nlm.nih.gov/21976813/


DIABETES AND IMPAIRED GLUCOSE REGULATION

Fluoride and impaired glucose tolerance

Link: https://fluoridealert.org/studies/diabetes01/


Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activity.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132568/


Reversible impairment of glucose tolerance in patients with endemic fluorosis. Fluoride Collaborative Study Group

Link: https://pubmed.ncbi.nlm.nih.gov/8405753/


Topical fluorides: effects on physiologic and biochemical processes

Link: https://pubmed.ncbi.nlm.nih.gov/3475325/

THYROID DYSFUNCTION


Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water

Link: https://jech.bmj.com/content/69/7/619?sid=387994a1-4d28-493a-bef6-8fdf845ecbb0

Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children

Link: https://pubmed.ncbi.nlm.nih.gov/31698198/


Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children's intelligence in endemic fluorosis area in Tianjin, China

Link: https://pubmed.ncbi.nlm.nih.gov/25556215/


Effects of high iodine and high fluorine on children's intelligence and the metabolism of iodine and fluorine

Link: https://pubmed.ncbi.nlm.nih.gov/7859263/


Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status

Link: https://pubmed.ncbi.nlm.nih.gov/30316182/


GASTROINTESTINAL DISORDERS AND DISTRESS

Fluoride-induced gastric symptoms in human clinical trials

Link: https://fluoridealert.org/studies/gastric01/


WWA ARTICLE: Jupiter in Pisces and Picking Up the Long, Long Historical Fight Against Fluoride Poisoning


WWA VIDEO: Fluoride/Fluorine Poisoning Through Water and Pharmaceuticals

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